Pharmaceutical development of metronidazole loaded transferosome gel for skin delivery
نویسندگان
چکیده
Objective: The focus of this research was out whether a transfersomal gel formulation for transdermal delivery Metronidazole. Methods: Azole Antifungals include metronidazole, which is used to treat fungal and yeast infections. Transferosomes are supra-molecular aggregates that ultra-flexible have high ability penetrate mammalian skin intact. Drug encapsulation in various formulations containing ratios different drug concentrations (0.05, 0.1, 0.2, 0.3, 0.4, 0.5 g) Carbopol-934 (0.5, 1, 2 being researched use as transferosomal gel.Results: Entrapment efficiency (EE %), content, in-vitro permeation tests, stability investigations were performed on the produced formulations. vesicles spherical shape, confirmed by Transmission Electron Microscopy. Metronidazole successfully pinned with standardised content all formulations, according resultsThe 0.1 g optimised transferosome MG2 showed promising results, maximum release (94.32%) (94.32%). Conclusion: According report, transferosomes long-term mechanism metronidazole reasonably good stability.This study suggests may be tool
منابع مشابه
Transferosome: the Drug Loaded Ultradeformable Vesicles for Transdermal Drug Delivery
Now a days, The novel drug delivery system is creating a new interest in development of drug deliveries. Vesicular drug delivery system in also a part of this novel drug delivery system which is designed according to the recent demands of treatment like sustain release of drug in systemic circulation, definite dosing interval. Transferosomes are part of this vesicular drug delivery system which...
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ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns7.11848